1. Greenberg, J.H., LaPlaca, M.C., and McIntosh, T.K. PARP [Poly (ADP-ribose) Polymerase] Inhibitors as Neuroprotective Agents for Brain Injury. in PARP as a Therapeutic Target, ed. J. Zhang, CRC Press; Boca Raton, FL, 2002.
2. Shoichet, M.S., Tate, C.C., Baumann, M.D., LaPlaca, M.C. Strategies for Regeneration and Repair in the Injured CNS. Chapter in Indwelling Neural Implants: Strategies for Contending with the In Vivo Environment Frontiers in Neuroengineering Ed. W.M. Reichert, CRC Press, 2008. PMID: 21204406
3. LaPlaca, M.C., Lessing, M.C., Prado, G.R., Simon, C.M. Susceptibility of neuronal membranes to mechanical injury and implication for repair. In The Pathomechanics of Tissue Injury and Disease, and the Mechanophysiology of Healing. Ed. A. Gefen, Research Signpost; Kerala, India, 2009,
4. LaPlaca, M.C., Vernekar, V.N., Shoemaker, J.T., Cullen, D.K. Three-Dimensional Neuronal Cultures. Methods in Bioengineering: 3D Tissue Engineering, Eds. F. Berthiaume and J. Morgan, Artech House;, Boston, 2010.
5. Morrison, B. III, Cullen D.K., LaPlaca, M.C. In Vitro Models for Biomechanical Studies of Neural Tissues. in Neural Tissue Biomechanics, Ed. L. Bilston. Vol 3 in Studies in Mechanobiology, Tissue Engineering and Biomaterials, Series Ed. A. Gefen, Springer; Berlin Heidelberg, 2011.
6. LaPlaca, M.C. and Irons, H.R. Essential Concepts in Traumatic Brain Injury Neuropathology: Primary Injury, Secondary Injury, and Neuroplasticity. In Manual of Traumatic Brain Injury Management. Ed. F.S. Zollman. Demos Medical Publishing; New York, 2011.
7. LaPlaca, M.C. and Lessing, M.C. Assessment of Membrane Permeability after Traumatic Brain Injury. in Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessment, Vol. 2. Eds. J. Chen, X-M. Xu, Z.C. Xu, J.H. Zhang. Humana Press c/o Springer, New York, 2012.


1. Yourick, D.L., LaPlaca, M.C., and Meyerhoff, J.L. Norepinephrine-stimulated phosphatidylinositol metabolism in genetically epilepsy-prone and kindled rats. Brain Research 551: 315-318, 1991.
2. Rubin, Y., LaPlaca M.C., Smith D.H., Thibault L.E., and Lenkinski R.E. The effect of N-acetyl-aspartate acid on the intracellular free calcium concentration in NTera2-neurons. Neuroscience Letters 198: 209-212, 1995.
3. LaPlaca, M.C. and Thibault, L.E. An in vitro traumatic injury model to examine the response of NTera-2 neurons to a hydrodynamically-induced deformation. Annals of Biomedical Engineering 25(4): 365-377, 1997.
4. LaPlaca, M.C., Lee, V.M.-Y., and Thibault, L.E. An in vitro model of traumatic neuronal injury: loading rate dependent changes in acute cytosolic calcium and lactate dehydrogenase release. Journal of Neurotrauma 14(6): 355-368, 1997.
5. LaPlaca, M.C. and Thibault, L.E. Dynamic Mechanical Deformation of Neurons Triggers an Acute Calcium Response and Cell Injury Involving the N-Methyl-D-Aspartate Glutamate Receptor. Journal of Neuroscience Research 52:220-229, 1998.
6. LaPlaca, M.C., Raghupathi, R., Verma, A., Pieper, A.A., Saatman, K.E., Snyder, S.H., and McIntosh, T.K. Temporal patterns of poly(ADP-ribose) polymerase activation in the cortex following experimental traumatic brain injury in the rat. Journal of Neurochemistry 72(2): 205-213, 1999.
7. Zhang, C., Raghupathi, R., Saatman, K.E., LaPlaca, M.C., and T.K. McIntosh. Regional and temporal alterations in DNA fragmentation factor (DFF)-like proteins following experimental brain trauma in the rat. Journal of Neurochemistry 73(4): 1605-9, 1999.
8. LaPlaca, M.C., Zhang, J., Smith, F., Bareyre, F.M., Raghupathi, R., Li, J.-H., Graham, D.I., Snyder, S.H., and McIntosh, T.K. Pharmacologic inhibition of poly(ADP-ribose) polymerase is neuroprotective following traumatic brain injury in rats. Journal of Neurotrauma 18(4): 369-376, 2001.
9. Tate, M.C., Shear, D.A., Hoffman, S.W., Stein, D.G., LaPlaca, M.C. Biocompatibility of Methylcellulose-Based Constructs Designed for Intracerebral Gelation and Enhanced Cell Support Following Experimental Traumatic Brain Injury. Biomaterials 22(10): 1113-1123, 2001.
10. Tate, M.C., Shear, D.A., Hoffman, S.W., Stein, D.G., Archer, D.R., LaPlaca, M.C. Fibronectin promotes survival and migration of primary neural stem cells transplanted into the traumatically injured mouse brain. Cell Transplantation 11(3): 283-295, 2002. PMID: 12075994
11. Geddes, D.M., Cargill, R.S. II and LaPlaca, M.C. Mechanical stretch to neurons results in a strain rate and magnitude-dependent increase in plasma membrane permeability.Journal of Neurotrauma 20(10): 1039-1049, 2003. PMID: 14588120
12. Geddes, D.M., LaPlaca, M.C., and Cargill, R.S. II Susceptibility of hippocampal neurons to mechanically-induced injury. Experimental Neurology 184(1):420-7, 2003.
13. Tate, M.C, García, A.J., Keselowsky, B.G., Schumm, M.A., Archer, D.R., LaPlaca, M.C. Specific β1 integrins mediate neural stem cell adhesion, migration, and differentiation on laminin and fibronectin Molecular and Cellular Neuroscience 27: 22-31, 2004.
14. Shear, D., Tate, M., Archer, D., Hoffman, S., Hulce, V., LaPlaca, M., Stein, D. Neural progenitor cell transplants promote long-term functional recovery after traumatic brain injury. Brain Research 1026:11-22, 2004. PMID: 15476693
15. LaPlaca, M.C., Cullen, D.K., McLoughlin, J.J., Cargill, R.S., II. High rate shear strain of three-dimensional neural cell cultures: A new in vitro traumatic brain injury model Journal of Biomechanics 38(5): 1093-105, 2005. PMID: 15797591
16. Prado, G.R. Ross, J.D., DeWeerth, S.P., LaPlaca, M.C. Mechanical Trauma Induces Immediate Changes in Neuronal Network Activity Journal of Neural Engineering 2: 148-158, 2005. PMID: 16317239
17. Stabenfeldt, S.E., García, A.J., and LaPlaca, M.C. Thermoreversible Laminin-Functionalized Hydrogel for Neural Tissue Engineering, Journal of Biomedical Materials Research A 77(4):718-2, 2006. PMID: 16555267
18. Cullen, D.K. and LaPlaca, M.C. Neuronal response to high rate shear deformation depends on heterogeneity of the local strain field. Journal of Neurotrauma 23(9):1304-19, 2006. PMID: 16958583
19. Tate, C.C., Tate, M.C., LaPlaca, M.C. Fibronectin and Laminin Increase in the Mouse Brain Following Controlled Cortical Impact Injury Journal of Neurotrauma 24(1): 226-230, 2007. PMID: 17263686
20. Cullen, D.K, Vukasinovic, J., Glezer, A., and LaPlaca, M.C. Microfluidic Engineered High Cell Density Three-Dimensional Neural Cultures Journal of Neural Engineering 4(2):159-172, 2007. PMID: 17409489. Selected as a “Highlights of 2007” paper
21. Choi, Y., McClain, M.A., LaPlaca M.C., Frazier A.B., Allen M.G. Three dimensional MEMS microfluidic perfusion system for thick brain slice cultures. Biomed Microdevices 9(1):7-13. 2007 PMID: 17091392
22. Barker, J.M., Ratcliff, J.J., Goldstein, F.C., Ockerman, J., Wright, D.W., LaPlaca, M.C. Portable, reduced-length neuropsychological testing for mild traumatic brain injury via a novel immersive environment: A usability study. Journal of Medical Engineering & Technology 31(3):161–9, 2007.
23. Cullen, D.K., Lessing, M.C., and LaPlaca, M.C. Collagen-Dependent Neurite Outgrowth and Response to Dynamic Deformation in Three-Dimensional Neuronal Cultures Annals of Biomedical Engineering 35(5):835-46. 2007. PMID: 17385044
24. Keselowsky, B.G., Bridges, A.W., Burns, K.L., Tate, C.C., Babensee, J.E., LaPlaca, M.C., García, A.J. Role of Plasma Fibronectin in the Foreign Body Response to Biomaterials. Biomaterials 28(25):3626-31, 2007. PMID: 17521718
25. Cullen, D.K., Simon, C.M., LaPlaca, M.C. Strain rate-dependent induction of reactive astrogliosis and cell death in three-dimensional neuronal-astrocytic co-cultures. Brain Research 1158: 103-115, 2007. PMID: 17555726. Cover Article
26. Tate, C.C., Garcia, A.J., LaPlaca, M.C. Plasma Fibronectin is Neuroprotective Following Traumatic Brain Injury Experimental Neurology 207: 13-22, 2007. PMID: 17599836
27. Cullen, D.K., Stabenfeldt, S.E., Simon, C.M., Tate, C.C., LaPlaca, M.C. An In Vitro Neural Injury Model for Optimization of Tissue Engineered Constructs Journal of Neuroscience Research 85(16):3642-51, 2007. PMID: 17671988
28. LaPlaca, M.C., Simon, C.S., Prado, G.R., and Cullen, D.K. CNS Injury Biomechanics and Experimental Models. Chapter in Neurotrauma: New Insights into Pathology and Treatment Progress in Brain Research, vol 161; Eds. Weber and Maas Progress in Brain Research 161:13-26, 2007. PMID: 17618967
29. Hallow, D.M., Seeger, R.A., Kamaev, P.P., Prado, G.R., LaPlaca, M.C., Prausnitz, M.R.. Shear-induced intracellular loading of cells with molecules by controlled microfluidics. Biotechnol Bioeng. 99(4):846-54, 2008. PMID: 17879304
30. Irons, H.R., Cullen, D.C., Shapiro, N.P., Lambert, N.A, Lee, R.H., LaPlaca, M.C. Three-dimensional neural constructs: a novel platform for neurophysiological investigation J. Neural Eng. 5 333-341, 2008. PMID: 18756031
31. Vernekar, V.N., Cullen, D.K., Fogleman, N., Choi, Y., García, A.J., Allen, M.G., Brewer, G.J., LaPlaca, M.C. SU-8 2000 rendered cytocompatible for neuronal bioMEMS applications. J Biomed Mater Res A. 89(1):138-51, 2009. PMID: 18431778
32. Wester, B.A., Lee, R.H., and LaPlaca, M.C., Development and characterization of in vivo flexible electrodes compatible with large tissue displacements J. Neural Engineering 6(2):024002, 2009.
33. Simon, CM, Sharif S, Tan RP, LaPlaca MC. Spinal cord contusion causes acute plasma membrane damage. J Neurotrauma. 26(4):563-74, 2009. PMID: 19260780
34. Vukasinovic, J, Cullen, DK , LaPlaca, MC, and Glezer, A. A microperfused incubator for tissue mimetic 3D cultures Biomedical Microdevices 11(6):1155, 2009. PMID: 19562488
35. Tate, C.C., Shear, D.A., Tate, M.C., Archer, D.R., Stein, D.G., LaPlaca, M.C. Laminin and fibronectin scaffolds enhance neural stem cell transplantation into the injured brain. J Tissue Eng Regen Med.3(3):208-17, 2009. PMID: 19229887
36. McClain, M.A., LaPlaca, M.C., Allen, M.G. Spun-cast micromolding for etchless micropatterning of electrically functional PDMS structures. J. Micromech. Microeng. 19 107002: 1-6, 2009.
37. LaPlaca, M.C., Prado, G.R.. Neural mechanobiology and neuronal vulnerability to traumatic loading. J Biomech. 2010 Jan 5;43(1):71-8. PMID: 19811784
38. Wright, D.W., Goldstein, F.C., Kilgo, P., Brumfield, J.R., Ravichandran, T., Danielson, M.L., LaPlaca, M. Use of a novel technology for presenting screening measures to detect mild cognitive impairment in elderly patients. Int J Clin Pract 64(9):1190–1197, 2010. PMID:20497262
39. Stabenfeldt, S.E., Munglani, G., García, A.J., LaPlaca, M.C. Biomimetic microenvironment modulates neural stem cell survival, migration, and differentiation. Tissue Eng Part A. ;16(12):3747-58. 2010. PMID: 20666608
40. Cullen, D.K., Gilroy, M.E., Irons, H.R., LaPlaca, M.C. Synapse-to-neuron ratio is inversely related to neuronal density in mature neuronal cultures. Brain Research 1359:44-55, 2010. PMID: 20800585
41. McClain, M.A., Clements, I.P., Shafer, R.H., Bellamkonda, R.V., LaPlaca, M.C., Allen, M.G.. Highly-compliant, microcable neuroelectrodes fabricated from thin-film gold and PDMS. Biomed Microdevices 13(2):361-73, 2011. PMID: 21240559
42. Cullen D, Wolf JA, Vernekar VN, Vukasinovic J, LaPlaca MC. Neural Tissue Engineering and Biohybridized Microsystems for Neurobiological Investigation In Vitro (Part 1). Crit Rev Biomed Eng.;39(3):201-240, 2011. PMID: 21967303
43. Higgins, A.Z., Cullen, D.K., LaPlaca, M.C., Karlsson, J.O. Effects of freezing profile parameters on the survival of cryopreserved rat embryonic neural cells. J Neurosci Methods. 201(1):9-16. 2011. PMID: 21816171
44. Rajaraman, S., Choi, S-O., McClain, M.A., Ross, J.D., LaPlaca, M.C., and Allen, M.G. Metal-Transfer-Micromolded Three-Dimensional Microelectrode Arrays for in-vitro Brain-Slice Recordings Journal of Microelectromechanical Systems, 20(2): 396-409, 2011.
45. Shear, D.A., Tate, C.C., Tate, M.C., Archer, D.R., LaPlaca, M.C., Stein, D.G., Dunbar, G.L. Stem cell survival and functional outcome after traumatic brain injury is dependent on transplant timing and location. Restor Neurol Neurosci. 2011;29(4):215-25. PMID: 21697596
46. Stabenfeldt, S.E., Irons, H.R., LaPlaca, M.C. Stem cells and bioactive scaffolds as a treatment for traumatic brain injury. Curr Stem Cell Res Ther. 6(3):208-20, 2011. PMID: 21476977
47. Stabenfeldt, S.E., LaPlaca, M.C. Variations in rigidity and ligand density influence neuronal response in methylcellulose-laminin hydrogels. Acta Biomater. 7(12): 4102-8. 2011 PMID: 21839862
48. Cullen, D.K., Vernekar, V.N., LaPlaca, M.C. Trauma-Induced Plasmalemma Disruptions in Three-Dimensional Neural Cultures are Dependent on Strain Modality and Rate. J Neurotrauma. 28(11):2219-33, 2011, PMID: 22023556.
49. Wright, D.W., Nevarez, H., Kilgo, P., LaPlaca, M., Robinson, A., Fowler, S., Brumfield, J., and Goldstein, F.C. A Novel Technology to Screen for Cognitive Impairment in the Elderly Individuals American Journal of Alzheimer’s Disease & Other Dementias, 226(6): 484-91, 2011. PMID: 22110158
50. LaPlaca, M.C., Meaney, D.F. Perspectives on the role of bioengineering in neurotrauma research. J Neurotrauma. 28(11):2201-2, 2011. PMID: 22082448
51. Olivero, D., LaPlaca, M, Kottke, P.A. Ambient nanoelectrospray ionization with in-line microdialysis for spatially resolved transient biochemical monitoring within cell culture environments. Anal Chem. 84(4):2072-5, 2012. PMID: 22263997
52. White TE, Ford GD, Surles-Zeigler MC, Gates AS, LaPlaca MC, Ford BD. Gene expression patterns following unilateral traumatic brain injury reveals a local pro-inflammatory and remote anti-inflammatory response. BMC Genomics. 14: 282, 2013.PMCID:PMC3669032.
53. Gutowski SM, Templeman KL, South AB, Gaulding JC, Shoemaker JT, LaPlaca MC, Bellamkonda RV, Lyon LA, García AJ. Host response to microgel coatings on neural electrodes implanted in the brain. J Biomed Mater Res A. 2014 May;102(5):1486-99, 2014. PMID:23666919
54. Gutowski SM, Shoemaker JT, Templeman KL, Wei Y, Latour Jr RA, Bellamkonda RV, LaPlaca MC, García AJ. Protease-degradable PEG-maleimide coating with on-demand release of IL-1Ra to improve tissue response to neural electrodes. Biomaterials, in press.


1. LaPlaca, M.C., Newstetter, W.C., and Yoganathan, A.P., Problem-Based Learning in Biomedical Engineering Curricula, Proceedings of 31st ASEE/IEEE Frontiers in Education Conference, Reno, NV, October, 2001.
2. Choi, Y., Powers, R., Vernekar, V., Frazier, A.B. LaPlaca, M.C., Allen, M.G. High Aspect Ratio SU-8 Structures for 3-D Culturing of Neurons, Proceedings of IMECE2003, Washington, D.C., November, 2003.
3. LaPlaca, M.C., Prado, G.R., Cullen, D.K., Irons, H.R. High rate shear insult delivered to cortical neurons produces heterogeneous membrane permeability alterations. Conf Proc IEEE Eng Med Biol Soc. 2006;1:2384-7.PMID: 17946956
4. Cullen DK, Vukasinovic J, Glezer A, LaPlaca MC. High cell density three-dimensional neural co-cultures require continuous medium perfusion for survival. Conf Proc IEEE Eng Med Biol Soc. 2006;1:636-9. PMID: 17946846
5. LaPlaca, M.C., Prado, G.R., Cullen, D., Simon, C.M. Plasma membrane damage as a marker of neuronal injury. Conf Proc IEEE Eng Med Biol Soc. 2009. 1113-6, 2009. PMID: 19964751



1. LaPlaca, M.C. and Ziejewski, M. Biomechanics of Traumatic Brain Injury (TBI): A Review, Brain Injury Professional 1(1):10-14, 2004. (LaPlaca, M.C., Guest Editor)
2. Wildermuth, C.W. Wright, D.W., and LaPlaca, M.C. Overview of Computer-Assisted Cognitive Function Diagnostic and Assessment Tools, Brain Injury Professional 1(1):32-35, 2004. (LaPlaca, M.C., Guest Editor)
3. LaPlaca, M.C. The Difficulty of Concussion Diagnosis: Why it is so Challenging and What We Can Do About It. The Challenge, Brain Injury Association of America, Volume 7(3), Summer 2013.





LaPlaca, M.C. The Engineering of Stem Cells, MIT Enterprise Forum, Aired on PBS, Atlanta, GA, October 12, 2006.


LaPlaca, M.C., U.S. Senate Committee on Veteran’s Affairs, Hearing on Traumatic Brain Injury, Chairman, Senator D. Akaka presiding, Washington, DC, May 5, 2010.
LaPlaca, M.C., Interviewed for comment about “Cerebral organoids model human brain development and microcephaly” (Lancaster et el. Nature 501(7467):373,2013, in MIT Technology Review: “Miniature Human Brains Grown in Petri Dish”, August, 2013


NFL honors Georgia Tech-Emory team for brain injury detection system. Nov 12, 2014,-under-armour,-ge-announce-head-health-challenge-ii-winners?ref=0ap3000000427468
1. LaPlaca, M and Wright, D. Display Enhanced Testing for Concussions and mTBI: (DETECT), U.S. Patent No. 8,568,311, 2013.
2. Methods and Systems for Determining Balance Based on Non-Postural Information, 62/049,541, filed September 12, 2014.